Translational bundle · for Head of Translational Medicine
Connect molecular signals to patient outcomes
Cyto links every imaging study, omics file, and cytogenetic report to the OMOP person, visit, and specimen; Calculate runs cross-modal analysis on that same governed record. Translational evidence lives on one record instead of scattered across systems that never reconcile.
The problem today
Translational scientists can't reliably ask whether molecular, manufacturing, shipping, and clinical signals drive response, relapse, or toxicity because the artifacts and the clinical record live in disconnected systems.
Faster
Analysis without the data project
Assay results land already linked to person, specimen, and timepoint, so translational analysis starts in Calculate without a preliminary data-engineering effort.
Better
Cross-modal questions become native
Ask whether cryopreservation, manufacturing variance, shipping time, biomarkers, and clinical history affect CAR-T outcomes in one workspace, on one OMOP record.
Cheaper
One substrate, not stitched silos
Imaging, omics, cytogenetics, and clinical data resolve to the same governed record instead of requiring per-system integration projects to reconcile.
How this bundle composes
Connect molecular, manufacturing, shipping, and clinical signals to patient outcomes — now extending upstream toward first-in-human IND enablement across existing apps.
Calculate is the analytics hub where biostatisticians define cohorts once on the governed OMOP record and carry them through characterization, QC, AI-authored Briefings, and submission-grade outputs without rebuilding the analysis at each step.
Cyto is the translational data layer that connects molecular, imaging, and cytogenetic artifacts to the OMOP clinical record, so every assay result arrives already linked to a person, specimen, and timepoint.
Why it holds up
- Cyto stores and indexes imaging (DICOM and non-DICOM), genomics/omics files, and cytogenetics, each carrying metadata that joins it to OMOP person_id, visit, and specimen.
- Calculate reads that same OMOP record to build cohorts and characterization studies, so molecular features sit alongside clinical, manufacturing, and shipping signals in one analysis.
- Because linkage and provenance are first-class in Cyto, Calculate's Briefings can author submission-grade reports whose narrative, tables, and citations stay tied to the underlying translational data.
- Translational evidence becomes decision-grade only when specimen timing, assay results, imaging, genomics, prior therapy, visits, and outcomes are linked on one record — which is what this bundle delivers.
The apps in this bundle
Calculate is the analytics hub where biostatisticians define cohorts once on the governed OMOP record and carry them through characterization, QC, AI-authored Briefings, and submission-grade outputs without rebuilding the analysis at each step.
- Cross-modal questions become native: ask whether cryopreservation, manufacturing variance, shipping time, biomarkers, ePRO, and EHR history affect CAR-T outcomes in one workspace.
- A governed in-app data-science IDE is the primary surface: a reactive SQL/Python/R notebook (dependency-inferred cell-DAG, live co-editing, publish-as-data-app) on the Conduct-governed enclave, with every result egress-checked and snapshot-pinned for reproducibility — JupyterLab stays as a per-session escape hatch. Governed AI cells ride the same enclave: generate code from natural language or narrate a cell's output in prose, each egress-checked before any data reaches the model.
Cyto is the translational data layer that connects molecular, imaging, and cytogenetic artifacts to the OMOP clinical record, so every assay result arrives already linked to a person, specimen, and timepoint.
- The bridge between molecular, imaging, cytogenetic, and OMOP clinical data — no other layer in the platform connects these signals to outcomes.
- Ask a natural-language question across imaging, omics, and cytogenetics and get a cited answer grounded only in the subject's governed facts — no fact leaves the gateway.
See the Translational bundle in action
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