Commercial bundle · for Market Access & HEOR · Corp Dev / Portfolio Strategy
Turn the evidence moat into commercial decisions
Crucible and Corridor put program go/no-go economics and the payer value case on the same governed real-world evidence that ran the trial and earned the label — so portfolio strategy and market access stop starting from a blank spreadsheet.
The problem today
R&D portfolio and market-access teams decide a program's fate in disconnected spreadsheets and one-off consulting decks — eNPV models, payer value dossiers, and the real-world evidence behind them live in separate tools that never reconcile, so every board question and every HTA reviewer question triggers a bespoke re-analysis.
Faster
Decisions without the data project
Program economics and payer value models draw their inputs from the platform's own governed OMOP record instead of hand-assembled spreadsheets and licensed third-party extracts, so a go/no-go call or an HTA evidence response starts from live governed data rather than a fresh analysis.
Better
Real-world-conditioned, lineage-intact
Probability-of-success priors and cost-effectiveness inputs are conditioned on the sponsor's own real-world data through Calculate and Conduct, with lineage from every parameter back to the source record — the wedge portfolio-economics and HEOR incumbents built on licensed data structurally cannot match.
Cheaper
One engine, one evidence chain
Crucible and Corridor consume the same versioned Calculate methodology and governed OMOP substrate as the rest of the platform, replacing per-vendor eNPV and HEOR toolchains — and the re-keying between them — with one validation story.
How this bundle composes
Turn the real-world-evidence moat into commercial-lifecycle decisions — market access and HEOR (Corridor) plus R&D portfolio go/no-go and program economics (Crucible).
Crucible gives R&D portfolio strategy and corporate development a program go/no-go workspace on the shared Calculate engine — pipeline assets, base / bull / bear assumption sets, and eNPV and value-of-information views conditioned on the platform's own real-world data, with every decision captured as an attributed, hash-chained decision-of-record.
Corridor gives market-access and HEOR teams a governed home for the payer value case — real-world-conditioned cost-effectiveness and budget-impact models and AMCP / HTA value dossiers sourced from the same audited OMOP data that supported the trial and the label, with model inputs and evidence citations bound to the dossier as an inspection-ready system of record.
Why it holds up
- Crucible authors the pipeline — assets, programs, and named base / bull / bear assumption sets — and captures each go/no-go as an attributed, hash-chained decision-of-record, with a probabilistic eNPV fan chart drawn from Calculate.
- Corridor turns governed real-world evidence into cost-effectiveness and budget-impact models and AMCP / HTA value dossiers whose model inputs and evidence citations stay bound to the artifact — the payer value case is evidence-continuous with the trial and the label, not a bespoke re-analysis per reviewer question.
- Probability-of-success priors and health-economic inputs are conditioned on the platform's own governed OMOP data through Calculate — consumed as versioned artifacts, never re-implemented — so the same real-world evidence that supported the label parameterizes the commercial decision.
- Program economics run under an elevated corp-dev persona, org-private by default — a distinct governance surface from the clinical consent and DUA stack — while the value dossier is held as an inspection-ready, e-signed system of record.
The apps in this bundle
Crucible gives R&D portfolio strategy and corporate development a program go/no-go workspace on the shared Calculate engine — pipeline assets, base / bull / bear assumption sets, and eNPV and value-of-information views conditioned on the platform's own real-world data, with every decision captured as an attributed, hash-chained decision-of-record.
- Authors the actual pipeline — assets, programs, and named base/bull/bear assumption sets — and captures the go/no-go as an attributed, hash-chained decision-of-record, with a probabilistic eNPV fan chart from Calculate.
- RWD-conditioned probability-of-success is the wedge no portfolio-economics incumbent (Cytel / Berry / Certara) can match — PoS priors are conditioned on the platform's own real-world data via Calculate + Conduct, not analyst guesswork.
Corridor gives market-access and HEOR teams a governed home for the payer value case — real-world-conditioned cost-effectiveness and budget-impact models and AMCP / HTA value dossiers sourced from the same audited OMOP data that supported the trial and the label, with model inputs and evidence citations bound to the dossier as an inspection-ready system of record.
- CEA/BIA and MAIC/STC/NMA indirect comparisons run on the platform's own governed RWD via Calculate — the value case built on the RWE moat, not licensed third-party data.
- The value dossier is a 21 CFR Part 11 system-of-record, not a document store: each submitted version freezes to an immutable WORM seal and releases only under an e-signed reviewer sign-off, with the meaning-of-signature bound into a hash-chained ledger — so the payer-value case is tamper-evident and inspection-ready (ADR-COR-003 / ADR-PLT-046).
See the Commercial bundle in action
Every research ecosystem is unique. Let's discuss how CuRE can be configured for your team.